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Testosterone is converted to estrogen in fat cells, therefore burning a fat cell will release estrogen, which will cause an excess of free-floating estrogen, which in turn causes endometrial hyperplasia/hypermenorrhea. Untreated, endometrial hyperplasia can lead to endometrial cancer.

Estrogen dominance syndrome

Failure to eliminate estrogen: Liver's ability to neutralize estrogen to eliminate it from the body can be impaired by various causes.

Excessive conversion of progesterone to other hormones: Stress coping hormones such as cortisone are produced from progesterone. Thus, high stress can reduce the effects of progesterone and shift the hormone production in favor of other hormones. Large doses of progesterone have anti-stress effects and protect adrenal gland.

Problems converting fat cells to glucose? Leptin? Or enzyme?